Home > News
Apr 16, 2019

Visible‐Light Photoredox‐Catalyzed and Copper‐Promoted Trifluoromethoxylation of Arenediazonium Tetrafluoroborates


A photoredox‐catalyzed and copper‐promoted trifluoromethoxylation of arenediazonium tetrafluoroborates have been developed for the first time. Trifluoromethyl arylsulfonate (TFMS) was used as the trifluoromethoxylation reagent. This reaction is scalable and proceeds regioselectively under mild reaction conditions. Furthermore, mechanistic studies suggested that Cs[Cu(OCF3)2] intermediate might be generated during the reaction.

Dec 21, 2018

恭喜王丰博士,徐鹏博士的研究成果被Chemical Science接收!
Dec 12, 2018

Silver-mediated oxidative functionalization of alkylsilanes
A general approach to the functionalization of aliphatic C–Si bonds in the presence of silver salts and oxidants has been reported. This strategy encompasses a range of valuable C–Si transformations, including the direct conversions of a C–Si bond to C–OCF3, C–OBz, C–OCOCF3, C–SCF3, C–SCN, and C–N3 bonds. Among them, trifluoromethoxylation of alkylsilanes is reported for the first time. In addition, mechanistic studies indicate that this reaction may proceed through a radical mechanism.
恭喜王丰博士,杨浩东硕士的研究成果被Angewandte Chemie接收!
Dec 12, 2018

Silver‐Promoted Oxidative Benzylic C−H Trifluoromethoxylation

Abstract: A silver‐promoted oxidative benzylic C−H trifluoromethoxylation has been reported for the first time. With trifluoromethyl arylsulfonate as the trifluoromethoxylation reagent, various arenes, having diverse functional groups, undergo trifluoromethoxylation of their benzylic C−H bonds to form trifluoromethyl ethers under mild reaction conditions. In addition, the trifluoromethoxylation and the fluorination of methyl groups of electron‐rich arenes have been achieved to prepare α‐fluorobenzyl trifluoromethyl ethers in one step.
恭喜丛菲硕士,魏永亮博士的研究成果被Chem Commun接收!
Jun 13, 2018

Combining photoredox and silver catalysis for azidotrifluoromethoxylation of styrene

Abstract: The first example of an azidotrifluoromethoxylation of styrenes has been achieved by synergistic visible-light-mediated photoredox and silver catalysis. Trifluoromethyl arylsulfonate (TFMS) and the Zhdankin reagent were used as the trifluoromethoxylation reagent and the azide source, respectively. A good functional group tolerance and mild reaction conditions of this method are applicable to late-stage azidotrifluoromethoxylation of complex small molecules. Furthermore, the mechanistic investigations indicate the single-electron transfer involved in the reaction.
恭喜刘杰博后,魏永亮博士的研究成果被Journal of the American Chemical Society接收!
Jun 13, 2018

Cobalt-Catalyzed Trifluoromethoxylation of Epoxides
Abstract: A catalytic ring-opening reaction of epoxides by nucleophilic trifluoromethoxylation of trifluoromethyl arylsulfonate has been developed based on the use of a cobalt catalyst. This reaction provides an efficient, simple route for directly construction of a wide range of vicinal trifluoromethoxyhydrins under mild conditions. In addition, this method can convert terminal epoxides into target products with good chemo- and regioselectivity.